PPAN

Across TCGA patient cohorts, PPAN protein abundance is significantly associated with the RNA expression of many other genes, with 5,627 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PPAN-associated genes across cancer lineages are FCGR1A, LEMD3, and RANP4. Each is linked with PPAN in more than 2 cancer types. Because this analysis shows association rather than direction, both PPAN-to-partner and partner-to-PPAN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPAN versus FCGR1A in COAD, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPAN→partner) and Y-score (partner→PPAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FCGR1A →	+1.067	+0.559	.005	.005	3	3
HNSC	LEMD3 →	-0.556	-0.417	<.001	.001	3	3
BRCA	RANP4 →	-0.814	-0.495	.002	.009	3	2
HNSC	RERE-AS1 →	-0.738	-0.466	.002	<.001	3	2
COAD	MID1 →	-0.931	-0.752	.007	.004	2	3
COAD	MTRES1 →	+0.912	+0.629	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,627 associations by consensus.

PPAN vs FCGR1A — COAD

Explore this scatter interactively →