PPAN

Across TCGA pan-cancer cohorts, PPAN RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PPAN’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPAN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPAN is over-expressed in tumor.

COAD, KIRC, and KIRP are the cancer types where PPAN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPAN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.945	<.001	11	view →
KIRC	Male	IV	+0.716	<.001	11	view →
KIRP	All	III,IV	+0.810	<.001	10	view →
STAD	All	III,IV	+1.218	<.001	9	view →
LIHC	Male	II,III,IV	+1.034	<.001	9	view →
HNSC	Male	All	+0.768	<.001	8	view →
BLCA	All	All	+0.510	.012	5	view →
LUSC	Male	II,III,IV	+1.008	<.001	4	view →
ESCA	All	All	+0.766	.003	4	view →
READ	All	All	+0.606	.019	4	view →
BRCA	All	All	+0.320	.002	4	view →
CHOL	All	All	+1.718	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PPAN–COAD

Open the COAD breakdown →