PPAN

Across TCGA pan-cancer cohorts, PPAN RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PPAN data layer compared with 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PPAN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPAN expression acts as an unfavorable survival marker, although some lineages such as SCLC and HNSC show a favorable association.

ACC, KIRC, and SCLC are the cancer types where PPAN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.258	0.655	<.001	102	view →
KIRC	DFS	Tertile	All	0.488	0.685	<.001	88	view →
SCLC	OS	Tertile	All	0.574	0.233	.001	80	view →
KICH	DFS	Tertile	III,IV	0.059	1.000	.002	60	view →
KIRP	DFS	Median	All	0.851	0.964	<.001	58	view →
HNSC	OS	Median	III,IV	0.676	0.573	.012	37	view →
UVM	DFS	Quartile	All	0.350	0.793	.004	36	view →
LGG	DFS	Tertile	All	0.651	0.824	<.001	33	view →
LIHC	OS	Median	All	0.625	0.751	.004	29	view →
PRAD	DFS	Quartile	All	0.704	0.956	.001	24	view →
GBM	DFS	Tertile	All	0.466	0.222	.002	18	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PPAN–ACC (DFS)

Open the ACC breakdown →