PPAN

Across TCGA cell cohorts, PPAN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,558 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPAN-associated GO terms across cancer lineages are rRNA metabolic process, Ribosome biogenesis, and rRNA processing. Each is linked with PPAN in more than 18 cancer types. Because this analysis shows association rather than direction, both PPAN-to-partner and partner-to-PPAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA metabolic process grouped by PPAN-low versus PPAN-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPAN→partner) and Y-score (partner→PPAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	rRNA metabolic process →	+0.140	+1.420	<.001	<.001	3	19
OESOPHAGUS	Ribosome biogenesis →	+0.139	+1.521	<.001	<.001	3	19
OESOPHAGUS	rRNA processing →	+0.145	+1.420	<.001	<.001	3	19
BLOOD_Lymphoma	Maturation of SSU-rRNA →	+0.116	+1.082	<.001	<.001	3	18
URINARY_TRACT	Ribosomal small subunit biogenesis →	+0.121	+1.112	<.001	<.001	3	18
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.170	+1.431	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,558 associations by consensus.

rRNA metabolic process by PPAN expression — OESOPHAGUS

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