PPAN

Across TCGA cell cohorts, PPAN protein abundance is significantly associated with the RNA expression of many other genes, with 2,545 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PPAN-associated genes across cancer lineages are HERC3, ARGLU1, and ARHGEF7. Each is linked with PPAN in more than 5 cancer types. Because this analysis shows association rather than direction, both PPAN-to-partner and partner-to-PPAN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPAN versus HERC3 in OESOPHAGUS, with a Pearson correlation of -0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPAN→partner) and Y-score (partner→PPAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HERC3 →	-1.280	-0.739	<.001	<.001	3	6
LUNG_NSCLC_LUAD	ARGLU1 →	-0.802	-0.489	.004	.008	3	6
LUNG_SCLC	ARHGEF7 →	-1.832	-1.018	.001	<.001	3	6
LIVER	ITGA1 →	-1.612	-0.994	.001	.004	3	5
BLOOD_Leukemia	PDS5B →	-0.991	-0.603	.001	.007	3	5
OESOPHAGUS	MLPH →	-3.052	-0.902	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,545 associations by consensus.

PPAN vs HERC3 — OESOPHAGUS

Explore this scatter interactively →