PPAN-P2RY11

Across TCGA patient cohorts, PPAN-P2RY11 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,605 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PPAN-P2RY11-associated GO terms across cancer lineages are 5S class rRNA transcription by RNA polymerase III, Negative regulation of telomere capping, and Microtubule polymerization. Each is linked with PPAN-P2RY11 in more than 15 cancer types. Because this analysis shows association rather than direction, both PPAN-P2RY11-to-partner and partner-to-PPAN-P2RY11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5S class rRNA transcription by RNA polymerase III grouped by PPAN-P2RY11-low versus PPAN-P2RY11-high in ACC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPAN-P2RY11→partner) and Y-score (partner→PPAN-P2RY11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	5S class rRNA transcription by RNA polymerase III →	+0.051	+0.136	<.001	<.001	3	16
THYM	Negative regulation of telomere capping →	+0.051	+0.077	<.001	<.001	3	14
TGCT	Microtubule polymerization →	+0.031	+0.072	<.001	<.001	3	14
ACC	Maintenance of cell number →	+0.025	+0.129	.001	.009	1	16
LAML	Obsolete regulation of histone methylation →	+0.039	+0.080	.003	.002	2	15
LAML	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.074	+0.118	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,605 associations by consensus.

5S class rRNA transcription by RNA polymerase III by PPAN-P2RY11 expression — ACC

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