PPAN-P2RY11

Across TCGA pan-cancer cohorts, PPAN-P2RY11 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PPAN-P2RY11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPAN-P2RY11 RNA is repressed in tumor relative to normal tissue. In most cancer types PPAN-P2RY11 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BRCA are the cancer types where PPAN-P2RY11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPAN-P2RY11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.034	<.001	12	view →
KICH	All	All	−0.107	<.001	7	view →
BRCA	All	IV	+0.130	.005	4	view →
STAD	Female	All	−0.060	.022	2	view →
KIRP	Male	All	−0.055	.002	2	view →
LUSC	All	All	+0.033	.014	2	view →
BLCA	All	III,IV	−0.048	.044	1	view →
READ	All	All	−0.033	.045	1	view →
HNSC	Male	IV	+0.027	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PPAN-P2RY11–KIRC

Open the KIRC breakdown →