Across TCGA cell cohorts, POU6F1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU6F1-associated genes across cancer lineages are KRTAP5-4, OR2AK2, and HMX3. Each is linked with POU6F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU6F1-to-partner and partner-to-POU6F1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU6F1→partner) and Y-score (partner→POU6F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP5-4 →	+0.101	+4.977	<.001	.007	3	1
OVARY	OR2AK2 →	+0.060	+4.029	<.001	.009	3	1
LARGE_INTESTINE	HMX3 →	+0.471	+3.531	.005	.007	3	1
LARGE_INTESTINE	TMEM235 →	+0.007	+3.297	<.001	.002	3	1
LARGE_INTESTINE	HBQ1 →	+1.280	+3.404	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

POU6F1 survival (RNA) · tumor vs normal (RNA) · all POU6F1 data types