POU2F1

Across TCGA patient cohorts, POU2F1 mutation is significantly associated with the RNA expression of many other genes, with 2,257 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU2F1-associated genes across cancer lineages are RNU6-961P, RNU6-644P, and RNU6-1245P. Each is linked with POU2F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU2F1-to-partner and partner-to-POU2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-961P grouped by POU2F1-low versus POU2F1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU2F1→partner) and Y-score (partner→POU2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-961P →	+0.200	+4.342	<.001	.007	3	2
CESC	RNU6-644P →	+0.340	+3.608	<.001	.004	3	2
CESC	RNU6-1245P →	+0.242	+3.475	.002	.008	3	2
SKCM	MTND3P12 →	+0.070	+3.784	<.001	.002	3	2
HNSC	CTAG1B →	+0.103	+6.111	<.001	.002	3	2
HNSC	RNU6-12P →	+0.315	+5.124	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,257 associations by consensus.

RNU6-961P by POU2F1 expression — CESC

Explore this box plot interactively →