POU2F1

Across TCGA pan-cancer cohorts, POU2F1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of POU2F1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POU2F1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POU2F1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, BLCA, and STAD are the cancer types where POU2F1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POU2F1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.867	<.001	12	view →
BLCA	Female	III,IV	+0.891	<.001	11	view →
STAD	Male	II,III,IV	+1.095	<.001	9	view →
LIHC	Female	II,III,IV	+0.931	<.001	9	view →
KIRP	All	II,III,IV	+0.571	.007	7	view →
LUSC	All	II,III,IV	+0.595	<.001	6	view →
BRCA	All	III,IV	+0.527	<.001	6	view →
CHOL	Male	All	+1.768	<.001	5	view →
COAD	All	II,III,IV	+0.427	<.001	5	view →
KICH	All	All	−0.561	<.001	4	view →
LUAD	All	All	+0.381	.001	4	view →
THCA	All	All	−0.238	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

POU2F1–HNSC

Open the HNSC breakdown →