POU1F1

Across TCGA cell cohorts, POU1F1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible POU1F1-associated genes across cancer lineages are SPAM1, PRLHR, and WFDC12. Each is linked with POU1F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU1F1-to-partner and partner-to-POU1F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPAM1 grouped by POU1F1-low versus POU1F1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU1F1→partner) and Y-score (partner→POU1F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPAM1 →	+0.013	+4.906	<.001	.006	3	1
KIDNEY	PRLHR →	+0.030	+5.000	<.001	.005	3	1
KIDNEY	WFDC12 →	+0.066	+5.000	<.001	.005	3	1
KIDNEY	TEX48 →	+0.133	+5.000	<.001	.005	3	1
LUNG_NSCLC_LUAD	KCNK18 →	+0.014	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SPAM1 by POU1F1 expression — OESOPHAGUS

Explore this box plot interactively →