POU1F1

Across TCGA pan-cancer cohorts, POU1F1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of POU1F1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where POU1F1 RNA is repressed in tumor relative to normal tissue. In most cancer types POU1F1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and KICH are the cancer types where POU1F1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POU1F1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.334	<.001	11	view →
LUSC	Female	II,III,IV	−0.368	<.001	7	view →
KICH	All	III,IV	−0.117	.003	7	view →
THCA	Female	All	−0.136	<.001	3	view →
STAD	Male	All	+0.066	.010	3	view →
COAD	Female	III,IV	−0.116	.033	2	view →
UCEC	All	All	−0.103	.033	2	view →
KIRC	All	All	−0.054	.006	2	view →
PRAD	All	All	−0.053	.033	2	view →
CHOL	All	All	+0.068	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

POU1F1–LUAD

Open the LUAD breakdown →