POT1

Across TCGA cell cohorts, POT1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible POT1-associated genes across cancer lineages are SULT2A1, PNMA3, and BPIFA1. Each is linked with POT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POT1-to-partner and partner-to-POT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SULT2A1 grouped by POT1-low versus POT1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POT1→partner) and Y-score (partner→POT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SULT2A1 →	+0.358	+3.584	.005	<.001	3	2
LARGE_INTESTINE	PNMA3 →	+0.172	+3.781	<.001	.003	3	1
LARGE_INTESTINE	BPIFA1 →	+0.163	+3.425	<.001	<.001	3	1
LARGE_INTESTINE	F11 →	+0.039	+2.882	<.001	.005	3	1
BLOOD_Lymphoma	SPAM1 →	+0.047	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	BTNL3 →	+0.171	+3.893	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

SULT2A1 by POT1 expression — OVARY

Explore this box plot interactively →