POT1

Across TCGA pan-cancer cohorts, POT1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of POT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POT1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where POT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.375	<.001	12	view →
KIRP	All	IV	+1.045	<.001	11	view →
KIRC	Male	All	+0.485	<.001	11	view →
THCA	Male	III,IV	−0.714	<.001	10	view →
COAD	Male	All	+0.864	<.001	9	view →
BLCA	All	All	+0.592	<.001	8	view →
LUAD	Male	III,IV	+0.789	<.001	7	view →
LIHC	Male	All	+0.708	<.001	7	view →
READ	All	II,III,IV	+0.762	<.001	6	view →
BRCA	All	II,III,IV	+0.424	<.001	6	view →
LUSC	All	All	+0.603	<.001	5	view →
CHOL	Male	All	+1.176	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

POT1–HNSC

Open the HNSC breakdown →