POSTN

Across TCGA cell cohorts, POSTN mutation is significantly associated with the RNA expression of many other genes, with 156 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible POSTN-associated genes across cancer lineages are ATOH7, PHOX2B, and CLRN1. Each is linked with POSTN in more than 1 cancer types. Because this analysis shows association rather than direction, both POSTN-to-partner and partner-to-POSTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATOH7 grouped by POSTN-low versus POSTN-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POSTN→partner) and Y-score (partner→POSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ATOH7 →	+0.350	+3.376	<.001	.002	3	2
BLOOD_Leukemia	PHOX2B →	+0.017	+3.365	<.001	.005	3	2
BLOOD_Lymphoma	CLRN1 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	POTED →	+1.083	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR10H5 →	+0.119	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MRGPRE →	+0.019	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

ATOH7 by POSTN expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →