POSTN

Across TCGA pan-cancer cohorts, POSTN RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of POSTN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POSTN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POSTN is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

HNSC, LUAD, and KIRC are the cancer types where POSTN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POSTN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+4.518	<.001	12	view →
LUAD	Male	III,IV	+3.741	<.001	11	view →
KIRC	Male	II,III,IV	+1.870	<.001	11	view →
BLCA	Female	All	+2.859	<.001	9	view →
LUSC	Female	All	+2.307	<.001	7	view →
THCA	Male	All	+1.814	<.001	7	view →
BRCA	All	III,IV	+3.053	<.001	6	view →
STAD	Male	II,III,IV	+1.644	.002	6	view →
COAD	Male	II,III,IV	+1.374	.001	6	view →
CHOL	All	All	+2.975	<.001	5	view →
UCEC	All	All	−2.673	<.001	4	view →
READ	Male	All	+2.626	.019	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

POSTN–HNSC

Open the HNSC breakdown →