PORCN

Across TCGA patient cohorts, PORCN mutation is significantly associated with the RNA expression of many other genes, with 1,251 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PORCN-associated genes across cancer lineages are LINC01072, RNA5SP473, and MIR548AL. Each is linked with PORCN in more than 2 cancer types. Because this analysis shows association rather than direction, both PORCN-to-partner and partner-to-PORCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01072 grouped by PORCN-low versus PORCN-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PORCN→partner) and Y-score (partner→PORCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC01072 →	+0.145	+3.760	<.001	.004	3	3
CESC	RNA5SP473 →	+0.513	+3.603	.002	.008	3	2
UCEC	MIR548AL →	+0.110	+2.471	.002	.006	3	2
UCEC	CINP →	+0.213	+2.254	.007	.005	3	2
LUSC	RN7SL643P →	+0.076	+3.414	.001	.006	3	2
BRCA	OR2T1 →	+0.086	+6.878	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,251 associations by consensus.

LINC01072 by PORCN expression — CESC

Explore this box plot interactively →