PORCN

Across TCGA pan-cancer cohorts, PORCN RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PORCN data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher PORCN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PORCN expression acts as an unfavorable survival marker, although some lineages such as UVM and LGG show a favorable association.

MESO, UVM, and LGG are the cancer types where PORCN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Quartile	All	0.202	0.519	<.001	86	view →
UVM	DFS	Median	All	0.704	0.458	.003	39	view →
LGG	DFS	Tertile	All	0.562	0.290	<.001	35	view →
KIRP	DFS	Median	IV	0.036	0.526	.006	34	view →
LIHC	DFS	Tertile	All	0.464	0.632	<.001	28	view →
UCEC	DFS	Median	III,IV	0.683	0.451	.017	24	view →
ACC	DFS	Tertile	III,IV	0.548	0.109	.009	17	view →
LUSC	DFS	Tertile	III,IV	0.367	0.654	.014	15	view →
TGCT	DFS	Tertile	All	0.629	0.905	.012	14	view →
KIRC	DFS	Median	III,IV	0.571	0.349	.036	10	view →
OV	OS	Median	All	0.651	0.724	.033	8	view →
THYM	DFS	Median	All	0.832	0.967	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PORCN–MESO (DFS)

Open the MESO breakdown →