POP4

Across TCGA cell cohorts, POP4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POP4-associated genes across cancer lineages are COX6A2, ENPP6, and OR1K1. Each is linked with POP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both POP4-to-partner and partner-to-POP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6A2 grouped by POP4-low versus POP4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POP4→partner) and Y-score (partner→POP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ENPP6 →	+0.038	+3.793	.002	.007	3	1
LARGE_INTESTINE	OR1K1 →	+0.051	+3.747	<.001	.008	3	1
LARGE_INTESTINE	KRTAP5-3 →	+0.037	+4.217	<.001	.001	3	1
LARGE_INTESTINE	OOSP4A →	+0.074	+3.793	.007	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.243	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

COX6A2 by POP4 expression — LARGE_INTESTINE

Explore this box plot interactively →