POP4

Across TCGA pan-cancer cohorts, POP4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of POP4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POP4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where POP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.431	<.001	12	view →
KIRC	Female	All	+0.428	<.001	12	view →
BLCA	All	All	+0.579	<.001	10	view →
KIRP	All	II,III,IV	+0.479	<.001	10	view →
LIHC	Male	II,III,IV	+1.054	<.001	9	view →
THCA	Male	II,III,IV	−0.513	<.001	9	view →
COAD	All	II,III,IV	+0.269	<.001	8	view →
LUSC	All	II,III,IV	+0.876	<.001	7	view →
LUAD	All	All	+0.337	<.001	7	view →
BRCA	All	III,IV	+0.476	<.001	6	view →
CHOL	Female	All	+1.613	<.001	5	view →
STAD	All	All	+0.589	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

POP4–HNSC

Open the HNSC breakdown →