POP4

Across TCGA pan-cancer cohorts, POP4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated POP4 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher POP4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated POP4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BLCA show a favorable association.

UVM, LGG, and KIRC are the cancer types where POP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.288	0.886	<.001	71	view →
LGG	DFS	Median	All	0.634	0.842	<.001	54	view →
KIRC	DFS	Quartile	III,IV	0.607	0.285	.011	50	view →
LIHC	OS	Tertile	All	0.519	0.786	<.001	36	view →
ACC	DFS	Quartile	All	0.378	0.792	.002	32	view →
KICH	DFS	Quartile	II,III,IV	0.593	1.000	.008	29	view →
BLCA	OS	Quartile	IV	0.751	0.458	<.001	28	view →
UCEC	DFS	Tertile	All	0.764	0.887	<.001	26	view →
HNSC	OS	Median	All	0.619	0.790	.004	22	view →
LAML	DFS	Median	All	0.472	0.657	.008	22	view →
UCS	DFS	Quartile	II,III,IV	0.561	0.127	.010	18	view →
ESCA	DFS	Quartile	II,III,IV	0.510	0.258	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

POP4–UVM (DFS)

Open the UVM breakdown →