PON3

Across TCGA patient cohorts, PON3 mutation is significantly associated with the RNA expression of many other genes, with 644 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PON3-associated genes across cancer lineages are C9orf64, SMC1A, and TRIM51HP. Each is linked with PON3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PON3-to-partner and partner-to-PON3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf64 grouped by PON3-low versus PON3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PON3→partner) and Y-score (partner→PON3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C9orf64 →	+0.675	+2.949	.003	<.001	3	2
UCEC	SMC1A →	+0.640	+4.010	.001	<.001	3	2
HNSC	TRIM51HP →	+0.042	+4.655	<.001	.007	3	2
HNSC	RNU6-1127P →	+0.431	+4.912	<.001	.005	3	2
LUAD	SEPTIN14P19 →	+0.074	+5.343	<.001	.006	3	2
LUAD	GEMIN7P1 →	+0.172	+5.217	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 644 associations by consensus.

C9orf64 by PON3 expression — UCEC

Explore this box plot interactively →