PON3

Across TCGA pan-cancer cohorts, PON3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PON3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PON3 RNA is repressed in tumor relative to normal tissue. In most cancer types PON3 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and KIRC are the cancer types where PON3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PON3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−1.695	<.001	11	view →
KICH	Female	II,III,IV	−1.707	<.001	10	view →
KIRC	Male	II,III,IV	−0.908	<.001	8	view →
LUSC	Male	II,III,IV	−2.180	<.001	7	view →
UCEC	All	II,III,IV	−1.528	<.001	6	view →
LIHC	All	All	−1.070	<.001	6	view →
PAAD	All	All	+1.017	.033	4	view →
CHOL	All	All	−3.777	<.001	3	view →
THCA	Male	All	−0.894	<.001	3	view →
PRAD	All	All	−0.768	<.001	2	view →
BRCA	Female	All	−0.428	.030	2	view →
STAD	All	All	+0.601	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PON3–KIRP

Open the KIRP breakdown →