PON1

Across TCGA patient cohorts, PON1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,846 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PON1-associated proteins across cancer lineages are PPP1R9A_S840, PPP1R9A, and CA12. Each is linked with PON1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PON1-to-partner and partner-to-PON1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PON1 versus PPP1R9A_S840 in HNSC, with a Pearson correlation of 0.68.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PON1→partner) and Y-score (partner→PON1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPP1R9A_S840 →	+1.250	+0.602	<.001	<.001	3	6
LSCC	PPP1R9A →	+0.711	+0.741	<.001	<.001	3	5
LSCC	CA12 →	-1.356	-0.636	<.001	<.001	3	4
HNSC	DDAH1 →	+0.747	+0.777	<.001	<.001	3	4
LSCC	AHNAK2 →	-0.842	-0.485	.003	.002	3	4
LSCC	TNIK →	+0.412	+0.458	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,846 associations by consensus.

PON1 vs PPP1R9A_S840 — HNSC

Explore this scatter interactively →