PON1

Across TCGA pan-cancer cohorts, PON1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PON1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PON1 RNA is repressed in tumor relative to normal tissue. In most cancer types PON1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LIHC are the cancer types where PON1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PON1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.353	<.001	11	view →
KIRP	All	II,III,IV	−0.556	<.001	9	view →
LIHC	All	All	−1.162	<.001	7	view →
KICH	All	All	−0.330	<.001	7	view →
CHOL	All	All	−5.414	<.001	5	view →
LUSC	Male	II,III,IV	−0.433	<.001	5	view →
STAD	All	All	+0.526	.017	2	view →
PRAD	All	All	−0.432	.011	2	view →
THCA	All	All	−0.071	.005	2	view →
LUAD	All	All	+0.330	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PON1–KIRC

Open the KIRC breakdown →