PON1

Across TCGA pan-cancer cohorts, PON1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PON1 data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PON1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PON1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and PAAD show a favorable association.

KIRC, LIHC, and PAAD are the cancer types where PON1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.533	0.702	<.001	155	view →
LIHC	OS	Median	All	0.848	0.702	<.001	106	view →
PAAD	OS	Tertile	II,III,IV	0.713	0.422	.001	55	view →
MESO	OS	Median	II,III,IV	0.688	0.439	.004	54	view →
LGG	DFS	Median	All	0.819	0.653	<.001	54	view →
STAD	DFS	Quartile	All	0.515	0.740	<.001	47	view →
CHOL	DFS	Tertile	II,III,IV	0.095	0.482	.004	32	view →
CESC	DFS	Median	All	0.433	0.640	.001	32	view →
KIRP	DFS	Tertile	III,IV	0.162	0.686	.008	28	view →
HNSC	OS	Tertile	All	0.210	0.467	.003	27	view →
BLCA	DFS	Median	IV	0.195	0.505	.004	22	view →
SKCM	OS	Median	III,IV	0.528	0.291	<.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PON1–KIRC (OS)

Open the KIRC breakdown →