PON1

Across TCGA patient cohorts, PON1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PON1-associated genes across cancer lineages are Cyclin-B1, p62 Lck ligand, and 14-3-3_beta. Each is linked with PON1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PON1-to-partner and partner-to-PON1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PON1-low versus PON1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PON1→partner) and Y-score (partner→PON1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.607	+1.502	.003	.030	3	3
UCEC	p62 Lck ligand →	+0.398	+3.817	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.088	-3.432	.016	.005	3	1
UCEC	EGFR_pY1068 →	-0.218	-1.700	.018	.042	3	1
UCEC	Fibronectin →	-0.271	-1.896	.025	.015	3	1
UCEC	JNK_pT183_Y185 →	-0.144	-2.115	.020	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Cyclin-B1 by PON1 expression — UCEC

Explore this box plot interactively →