PON1

Across TCGA cell cohorts, PON1 RNA expression is significantly associated with the RNA expression of many other genes, with 3,957 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PON1-associated genes across cancer lineages are PON3, PPARGC1A, and METTL7A. Each is linked with PON1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PON1-to-partner and partner-to-PON1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PON1 versus PON3 in LIVER, with a Pearson correlation of 0.53.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PON1→partner) and Y-score (partner→PON1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PON3 →	+3.806	+1.412	<.001	<.001	3	7
CNS	PPARGC1A →	+1.183	+0.070	<.001	<.001	3	3
LIVER	METTL7A →	+2.810	+1.219	<.001	.001	3	3
LUNG_SCLC	C2orf15 →	+1.913	+1.493	<.001	<.001	3	3
LIVER	TOX3 →	+2.431	+1.195	<.001	.001	2	4
SKIN	ITGA7 →	+1.814	+0.059	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,957 associations by consensus.

PON1 vs PON3 — LIVER

Explore this scatter interactively →