PON1

Across TCGA cell cohorts, PON1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,420 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PON1-associated GO terms across cancer lineages are Negative regulation of stem cell differentiation, Lysosomal lumen acidification, and Negative regulation of chondrocyte development. Each is linked with PON1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PON1-to-partner and partner-to-PON1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of stem cell differentiation grouped by PON1-low versus PON1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PON1→partner) and Y-score (partner→PON1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of stem cell differentiation →	+0.157	+1.256	.006	.001	3	5
LUNG_NSCLC_LUAD	Lysosomal lumen acidification →	+0.060	+0.359	<.001	.001	3	5
LIVER	Negative regulation of chondrocyte development →	-1.040	-1.078	.007	.009	3	5
LUNG_SCLC	Substrate-dependent cell migration, cell extension →	+0.148	+1.160	.007	.001	3	5
LUNG_NSCLC_LUAD	Regulation of myoblast fusion →	+0.058	+0.538	.002	.006	3	4
UPPER_AERODIGESTIVE_TRACT	Endosomal lumen acidification →	+0.076	+0.071	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,420 associations by consensus.

Negative regulation of stem cell differentiation by PON1 expression — LUNG_SCLC

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