PON1

Across TCGA cell cohorts, PON1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PON1-associated genes across cancer lineages are SCGB1D1, OR10T2, and PRAMEF10. Each is linked with PON1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PON1-to-partner and partner-to-PON1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1D1 grouped by PON1-low versus PON1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PON1→partner) and Y-score (partner→PON1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SCGB1D1 →	+2.546	+4.269	<.001	.005	3	1
LUNG_SCLC	OR10T2 →	+0.145	+4.044	.002	.009	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
BLOOD_Leukemia	MRGPRX4 →	+0.015	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SCGB1D1 by PON1 expression — LUNG_SCLC

Explore this box plot interactively →