POM121L2

Across TCGA cell cohorts, POM121L2 mutation is significantly associated with the RNA expression of many other genes, with 250 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POM121L2-associated genes across cancer lineages are UHRF1BP1L, TBC1D15, and SPACA5. Each is linked with POM121L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POM121L2-to-partner and partner-to-POM121L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1BP1L grouped by POM121L2-low versus POM121L2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POM121L2→partner) and Y-score (partner→POM121L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UHRF1BP1L →	+0.555	+3.364	.004	.002	3	2
LARGE_INTESTINE	TBC1D15 →	+0.564	+3.169	.006	.009	3	2
LUNG_NSCLC_LUSC	SPACA5 →	+0.095	+3.807	<.001	.003	3	1
SKIN	C2CD4B →	+0.036	+3.684	<.001	.006	3	1
LUNG_SCLC	OR1P1 →	+0.228	+4.058	<.001	.001	3	1
LUNG_SCLC	SPANXN2 →	+0.336	+3.070	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 250 associations by consensus.

UHRF1BP1L by POM121L2 expression — LARGE_INTESTINE

Explore this box plot interactively →