POM121C

Across TCGA patient cohorts, POM121C mutation is significantly associated with the RNA expression of many other genes, with 2,973 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POM121C-associated genes across cancer lineages are MRPL54, HCAR1, and SLC22A4. Each is linked with POM121C in more than 3 cancer types. Because this analysis shows association rather than direction, both POM121C-to-partner and partner-to-POM121C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL54 grouped by POM121C-low versus POM121C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POM121C→partner) and Y-score (partner→POM121C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MRPL54 →	+0.647	+3.335	<.001	.005	3	3
UCEC	HCAR1 →	-0.442	-3.311	<.001	<.001	3	3
UCEC	SLC22A4 →	-0.505	-1.424	.001	.004	3	3
UCEC	RNU4-58P →	+0.143	+1.963	<.001	.001	3	3
UCEC	C4orf46 →	+0.368	+1.275	.006	.004	3	3
UCEC	LINC00954 →	-0.248	-1.679	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,973 associations by consensus.

MRPL54 by POM121C expression — COAD

Explore this box plot interactively →