POM121C

Across TCGA cell cohorts, POM121C mutation is significantly associated with the mutation status of many other genes, with 1,357 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POM121C-associated genes across cancer lineages are CNTN4, KCNH7, and TMEM67. Each is linked with POM121C in more than 3 cancer types. Because this analysis shows association rather than direction, both POM121C-to-partner and partner-to-POM121C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNTN4 grouped by POM121C-low versus POM121C-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POM121C→partner) and Y-score (partner→POM121C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CNTN4 →	+2.548	+2.641	.008	.008	1	4
BLOOD_Leukemia	KCNH7 →	+2.071	+2.256	.009	.009	1	4
UPPER_AERODIGESTIVE_TRACT	TMEM67 →	+5.392	+5.392	.004	.004	1	4
LARGE_INTESTINE	WDFY4 →	+1.243	+2.237	.008	.008	1	4
BREAST	MELTF →	+3.222	+3.222	.009	.009	1	4
UPPER_AERODIGESTIVE_TRACT	DYSF →	+4.392	+4.954	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,357 associations by consensus.

CNTN4 by POM121C expression — SKIN

Explore this box plot interactively →