POLRMT

Across TCGA cell cohorts, POLRMT mutation is significantly associated with the RNA expression of many other genes, with 459 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLRMT-associated genes across cancer lineages are IFNL1, DEFB134, and OR2J3. Each is linked with POLRMT in more than 2 cancer types. Because this analysis shows association rather than direction, both POLRMT-to-partner and partner-to-POLRMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNL1 grouped by POLRMT-low versus POLRMT-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLRMT→partner) and Y-score (partner→POLRMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFNL1 →	+0.243	+2.685	.009	.005	3	2
KIDNEY	DEFB134 →	+0.038	+4.121	<.001	.006	3	2
BLOOD_Lymphoma	OR2J3 →	+0.007	+3.867	<.001	.002	3	2
BLOOD_Lymphoma	KRTAP19-3 →	+0.036	+4.247	<.001	.004	3	2
BREAST	CCDC182 →	+0.065	+4.672	<.001	.002	3	2
SKIN	OR52I1 →	+0.015	+3.502	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 459 associations by consensus.

IFNL1 by POLRMT expression — BLOOD_Leukemia

Explore this box plot interactively →