POLRMT

Across TCGA pan-cancer cohorts, POLRMT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of POLRMT’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where POLRMT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLRMT is over-expressed in tumor.

STAD, COAD, and LIHC are the cancer types where POLRMT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLRMT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	II,III,IV	+1.210	<.001	10	view →
COAD	Female	All	+0.922	<.001	10	view →
LIHC	Male	II,III,IV	+1.180	<.001	9	view →
BLCA	Male	All	+0.673	<.001	9	view →
HNSC	Male	II,III,IV	+0.505	<.001	9	view →
LUSC	Male	II,III,IV	+0.878	<.001	7	view →
KIRC	Female	All	+0.354	<.001	7	view →
READ	All	All	+0.834	<.001	5	view →
THCA	All	All	+0.211	<.001	5	view →
UCEC	All	III,IV	+0.540	.004	4	view →
CHOL	Female	All	+1.413	<.001	3	view →
ESCA	All	All	+0.816	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

POLRMT–STAD

Open the STAD breakdown →