POLR3GL

mutation — cross-omics
Cross-omicsMUTATION → IMMUNEPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, POLR3GL mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3GL-associated genes across cancer lineages are CD8+ naive T-cells and Adipocytes. Each is linked with POLR3GL in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3GL-to-partner and partner-to-POLR3GL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ naive T-cells grouped by POLR3GL-low versus POLR3GL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3GL→partner) and Y-score (partner→POLR3GL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCD8+ naive T-cells →+0.065+2.850<.001.03532
UCECAdipocytes →+0.030+3.244.006.02032
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD8+ naive T-cells by POLR3GL expression — UCEC

Box plot of CD8+ naive T-cells in POLR3GL-low vs POLR3GL-high samples in UCEC.

Explore this box plot interactively →

Exploration