POLR3GL

Across TCGA cell cohorts, POLR3GL RNA expression is significantly associated with the go_rna of many other GO terms, with 2,817 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLR3GL-associated GO terms across cancer lineages are Membrane fusion, Positive regulation of insulin-like growth factor receptor signaling pathway, and Protoporphyrinogen IX metabolic process. Each is linked with POLR3GL in more than 8 cancer types. Because this analysis shows association rather than direction, both POLR3GL-to-partner and partner-to-POLR3GL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane fusion grouped by POLR3GL-low versus POLR3GL-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3GL→partner) and Y-score (partner→POLR3GL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Membrane fusion →	+0.046	+0.739	.004	.008	3	9
SOFT_TISSUE	Positive regulation of insulin-like growth factor receptor signaling pathway →	-1.215	-0.871	<.001	<.001	3	8
URINARY_TRACT	Protoporphyrinogen IX metabolic process →	+0.149	+1.105	.003	.005	3	8
UPPER_AERODIGESTIVE_TRACT	COPII-coated vesicle budding →	+0.075	+0.599	.002	.002	3	8
LUNG_SCLC	Maturation of SSU-rRNA →	-0.129	-0.736	<.001	.001	3	8
URINARY_TRACT	Heme B biosynthetic process →	+0.149	+1.105	.003	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,817 associations by consensus.

Membrane fusion by POLR3GL expression — LUNG_NSCLC_LUSC

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