POLR3G

Across TCGA patient cohorts, POLR3G mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3G-associated genes across cancer lineages are JNK2, 14-3-3_beta, and A-Raf_pS299. Each is linked with POLR3G in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3G-to-partner and partner-to-POLR3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by POLR3G-low versus POLR3G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3G→partner) and Y-score (partner→POLR3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.246	+3.196	.001	.009	3	2
UCEC	14-3-3_beta →	-0.078	-2.973	.046	.035	3	1
UCEC	A-Raf_pS299 →	-0.099	-1.584	.034	.036	3	1
UCEC	IGFBP2 →	-0.742	-1.584	.003	.036	3	1
UCEC	Ku80 →	+0.227	+1.594	.014	.042	3	1
UCEC	MAPK_pT202_Y204 →	-0.436	-1.700	.018	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

JNK2 by POLR3G expression — UCEC

Explore this box plot interactively →