POLR3G

Across TCGA pan-cancer cohorts, POLR3G RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated POLR3G data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher POLR3G RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLR3G expression acts as an unfavorable survival marker, although some lineages such as READ and GBM show a favorable association.

BLCA, KICH, and MESO are the cancer types where POLR3G RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.331	0.525	<.001	97	view →
KICH	DFS	Median	II,III,IV	0.672	1.000	.001	78	view →
MESO	OS	Tertile	All	0.231	0.496	.002	72	view →
KIRP	DFS	Median	All	0.781	0.921	<.001	65	view →
KIRC	DFS	Tertile	II,III,IV	0.378	0.657	<.001	65	view →
UVM	DFS	Tertile	III,IV	0.236	0.876	<.001	62	view →
LIHC	DFS	Tertile	All	0.452	0.624	<.001	49	view →
LGG	OS	Median	All	0.748	0.866	<.001	40	view →
READ	DFS	Median	All	0.727	0.336	.003	38	view →
UCEC	DFS	Quartile	All	0.462	0.775	<.001	38	view →
LUAD	OS	Tertile	All	0.744	0.856	.001	29	view →
PAAD	OS	Quartile	II,III,IV	0.341	0.687	.002	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

POLR3G–BLCA (OS)

Open the BLCA breakdown →