POLR3G

Across TCGA pan-cancer cohorts, POLR3G RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of POLR3G’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where POLR3G RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR3G is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

KIRP, COAD, and LUSC are the cancer types where POLR3G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR3G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.456	<.001	9	view →
COAD	All	III,IV	+1.227	<.001	8	view →
LUSC	Male	II,III,IV	+1.168	<.001	8	view →
BLCA	All	III,IV	+0.680	<.001	8	view →
LUAD	Male	II,III,IV	+0.819	<.001	7	view →
HNSC	All	All	+0.542	.001	7	view →
KIRC	Male	II,III,IV	+0.435	<.001	7	view →
READ	All	III,IV	+1.690	.010	6	view →
LIHC	Male	II,III,IV	+0.835	<.001	6	view →
STAD	All	II,III,IV	+0.775	.002	6	view →
CHOL	Male	All	+0.940	<.001	2	view →
THCA	Female	All	−0.309	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

POLR3G–KIRP

Open the KIRP breakdown →