POLR3D

Across TCGA patient cohorts, POLR3D mutation is significantly associated with the RNA expression of many other genes, with 1,076 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3D-associated genes across cancer lineages are MIR920, RNU6-996P, and RNU1-136P. Each is linked with POLR3D in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3D-to-partner and partner-to-POLR3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR920 grouped by POLR3D-low versus POLR3D-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3D→partner) and Y-score (partner→POLR3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR920 →	+0.371	+4.539	<.001	.008	3	2
PRAD	RNU6-996P →	+0.363	+7.939	<.001	.008	3	2
COAD	RNU1-136P →	+0.507	+4.283	.004	.001	3	2
UCEC	LSP1P1 →	+0.230	+1.921	.002	.006	3	2
SKCM	MYLK-AS2 →	+0.083	+2.623	.002	.008	3	2
UCEC	CBARP →	+0.836	+2.914	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,076 associations by consensus.

MIR920 by POLR3D expression — CESC

Explore this box plot interactively →