POLR3D

Across TCGA pan-cancer cohorts, POLR3D RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of POLR3D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where POLR3D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR3D is over-expressed in tumor.

KIRP, KIRC, and HNSC are the cancer types where POLR3D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR3D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+1.119	<.001	11	view →
KIRC	Female	All	+0.634	<.001	11	view →
HNSC	Male	All	+0.616	<.001	11	view →
COAD	Female	All	+0.874	<.001	10	view →
LUAD	Male	II,III,IV	+0.696	<.001	9	view →
LIHC	All	II,III,IV	+0.655	<.001	9	view →
STAD	Male	II,III,IV	+0.896	<.001	8	view →
READ	All	All	+0.618	.002	7	view →
LUSC	Male	II,III,IV	+0.624	<.001	6	view →
CHOL	Male	All	+2.498	<.001	5	view →
UCEC	All	III,IV	+0.850	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

POLR3D–KIRP

Open the KIRP breakdown →