POLR3D

Across TCGA pan-cancer cohorts, POLR3D RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated POLR3D data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher POLR3D RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLR3D expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

MESO, ACC, and KIRP are the cancer types where POLR3D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.267	0.545	<.001	108	view →
ACC	DFS	Median	All	0.368	0.783	<.001	70	view →
KIRP	DFS	Tertile	All	0.838	0.951	.002	68	view →
BLCA	OS	Tertile	II,III,IV	0.304	0.583	<.001	64	view →
LIHC	DFS	Median	All	0.461	0.637	<.001	59	view →
KICH	DFS	Quartile	II,III,IV	0.589	1.000	.010	45	view →
HNSC	DFS	Median	IV	0.729	0.551	<.001	33	view →
STAD	DFS	Tertile	II,III,IV	0.353	0.650	.013	26	view →
PAAD	OS	Tertile	All	0.315	0.616	.001	22	view →
LUAD	OS	Median	All	0.769	0.853	.017	20	view →
KIRC	DFS	Median	All	0.867	0.721	.001	18	view →
SARC	OS	Quartile	All	0.645	0.816	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

POLR3D–MESO (OS)

Open the MESO breakdown →