POLR3D

Across TCGA patient cohorts, POLR3D mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3D-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with POLR3D in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3D-to-partner and partner-to-POLR3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by POLR3D-low versus POLR3D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3D→partner) and Y-score (partner→POLR3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.242	+2.000	.004	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.687	+3.459	.003	.005	3	2
UCEC	EGFR_pY1068 →	-0.198	-1.584	.044	.036	3	1
UCEC	ERK2 →	+0.179	+1.584	.018	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.097	-1.990	.047	.030	3	1
UCEC	GATA3 →	+0.158	+2.515	.033	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PCNA by POLR3D expression — UCEC

Explore this box plot interactively →