POLR3D

Across TCGA cell cohorts, POLR3D RNA expression is significantly associated with the go_rna of many other GO terms, with 3,770 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR3D-associated GO terms across cancer lineages are tRNA transcription, tRNA transcription by RNA polymerase III, and Termination of RNA polymerase III transcription. Each is linked with POLR3D in more than 17 cancer types. Because this analysis shows association rather than direction, both POLR3D-to-partner and partner-to-POLR3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA transcription grouped by POLR3D-low versus POLR3D-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3D→partner) and Y-score (partner→POLR3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	tRNA transcription →	+0.169	+1.283	<.001	<.001	3	18
BONE	tRNA transcription by RNA polymerase III →	+0.177	+1.373	<.001	<.001	3	17
BONE	Termination of RNA polymerase III transcription →	+0.133	+0.907	.001	.003	2	15
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase III promoter →	+0.097	+0.812	<.001	<.001	3	14
BONE	Positive regulation of telomere capping →	+0.128	+0.829	.001	.005	3	13
SKIN	RNA surveillance →	+0.061	+0.944	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,770 associations by consensus.

tRNA transcription by POLR3D expression — BONE

Explore this box plot interactively →