POLR3B

Across TCGA patient cohorts, POLR3B mutation is significantly associated with the RNA expression of many other genes, with 2,811 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3B-associated genes across cancer lineages are IGHD6-19, SCYL1, and FEN1. Each is linked with POLR3B in more than 2 cancer types. Because this analysis shows association rather than direction, both POLR3B-to-partner and partner-to-POLR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD6-19 grouped by POLR3B-low versus POLR3B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3B→partner) and Y-score (partner→POLR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGHD6-19 →	+1.306	+3.588	<.001	.001	3	3
LUSC	SCYL1 →	+0.532	+3.229	<.001	.009	3	3
SKCM	FEN1 →	+0.555	+3.093	.001	<.001	3	3
SKCM	HSF1 →	+0.471	+1.925	<.001	.009	3	3
SKCM	CENPO →	+0.451	+3.632	.004	.001	3	3
UCEC	TIMM21 →	+0.401	+1.765	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,811 associations by consensus.

IGHD6-19 by POLR3B expression — COAD

Explore this box plot interactively →