POLR3B

Across TCGA pan-cancer cohorts, POLR3B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated POLR3B data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher POLR3B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated POLR3B expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

UCS, LUAD, and BLCA are the cancer types where POLR3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	II,III,IV	0.576	0.144	<.001	64	view →
LUAD	DFS	Quartile	All	0.733	0.879	.006	36	view →
BLCA	OS	Median	II,III,IV	0.329	0.499	.007	26	view →
OV	OS	Quartile	II,III,IV	0.791	0.883	.006	24	view →
SCLC	OS	Tertile	II,III,IV	0.733	0.268	.001	21	view →
LGG	OS	Tertile	All	0.748	0.948	<.001	16	view →
LUSC	DFS	Quartile	III,IV	0.386	0.993	.021	16	view →
BRCA	DFS	Quartile	III,IV	0.629	0.414	.024	16	view →
COAD	OS	Median	IV	0.465	0.805	.010	15	view →
GBM	DFS	Quartile	All	0.410	0.195	.024	15	view →
PRAD	DFS	Tertile	All	0.937	0.859	.010	14	view →
LIHC	OS	Median	All	0.717	0.839	.005	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

POLR3B–UCS (DFS)

Open the UCS breakdown →