POLR2J

Across TCGA patient cohorts, POLR2J protein abundance is significantly associated with the RNA expression of many other genes, with 2,245 significant associations in total. OV shows the largest number of these associations.

The most reproducible POLR2J-associated genes across cancer lineages are MTHFD1, NUP93, and TAF1C. Each is linked with POLR2J in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2J-to-partner and partner-to-POLR2J results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR2J versus MTHFD1 in COAD, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2J→partner) and Y-score (partner→POLR2J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTHFD1 →	+1.013	+1.276	.001	<.001	3	1
COAD	NUP93 →	+1.132	+1.359	.001	<.001	3	1
COAD	TAF1C →	+0.921	+1.220	.003	<.001	3	1
COAD	PIEZO1 →	+1.353	+1.033	.002	.007	3	1
COAD	DOT1L →	+1.031	+1.112	.002	.004	3	1
COAD	SMG9 →	+0.942	+1.632	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,245 associations by consensus.

POLR2J vs MTHFD1 — COAD

Explore this scatter interactively →