POLR2J

Across TCGA cell cohorts, POLR2J RNA expression is significantly associated with the go_rna of many other GO terms, with 3,551 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLR2J-associated GO terms across cancer lineages are Peptidyl-glutamic acid carboxylation, Protein carboxylation, and tRNA dihydrouridine synthesis. Each is linked with POLR2J in more than 12 cancer types. Because this analysis shows association rather than direction, both POLR2J-to-partner and partner-to-POLR2J results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-glutamic acid carboxylation grouped by POLR2J-low versus POLR2J-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2J→partner) and Y-score (partner→POLR2J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Peptidyl-glutamic acid carboxylation →	+0.084	+0.430	<.001	.002	3	13
LUNG_NSCLC_LUAD	Protein carboxylation →	+0.084	+0.430	<.001	.002	3	13
BLOOD_Myeloma	tRNA dihydrouridine synthesis →	+0.091	+0.923	<.001	<.001	3	11
BONE	Establishment of protein localization to chromosome →	+0.144	+0.721	<.001	.002	3	10
OVARY	Negative regulation of synaptic vesicle exocytosis →	+0.111	+0.553	<.001	<.001	3	9
BONE	Positive regulation of isotype switching to IgG isotypes →	+0.145	+0.490	<.001	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,551 associations by consensus.

Peptidyl-glutamic acid carboxylation by POLR2J expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →