POLR2F

Across TCGA patient cohorts, POLR2F mutation is significantly associated with the RNA expression of many other genes, with 424 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR2F-associated genes across cancer lineages are MIR4510, LINC02013, and RNU7-60P. Each is linked with POLR2F in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2F-to-partner and partner-to-POLR2F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4510 grouped by POLR2F-low versus POLR2F-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2F→partner) and Y-score (partner→POLR2F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4510 →	+0.297	+5.342	<.001	.002	3	2
BRCA	LINC02013 →	+0.203	+7.725	<.001	<.001	3	2
SKCM	RNU7-60P →	+0.314	+4.495	<.001	.007	3	2
SKCM	TFAMP2 →	+0.072	+4.454	<.001	.002	3	2
BLCA	CCDC58P2 →	+0.252	+5.788	<.001	.003	3	2
SKCM	LINC02654 →	+0.060	+5.212	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 424 associations by consensus.

MIR4510 by POLR2F expression — CESC

Explore this box plot interactively →